NLRP2 antibody

Catalog No. ABIN7116907

This Rabbit Polyclonal antibody specifically detects NLRP2 in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for NLRP2 antibody (ABIN7116907)

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-NLRP2 Antibody

Purpose: NLRP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: NLR family, pyrin domain containing 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Alternative Name: NLRP2

Background:

Synonyms: NACHT, LRR and PYD domains-containing protein 2|Nucleotide-binding site protein 1|PYRIN domain and NACHT domain-containing protein 1|PYRIN-containing APAF1-like protein 2|NLRP2|NALP2|NBS1|PAN1|PYPAF2

Background: Suppresses TNF-and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Molecular Weight: 105-110 kDa

Gene ID: 55655

UniProt: Q9NX02

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome