PPARGC1B antibody

Catalog No. ABIN7117364

The Rabbit Polyclonal anti-PPARGC1B antibody is suitable to detect PPARGC1B in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for PPARGC1B antibody (ABIN7117364)

Target: PPARGC1B (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 beta (PPARGC1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARGC1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PPARGC1B Antibody

Purpose: PPARGC1B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: peroxisome proliferator-activated receptor gamma, coactivator 1 beta

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PPARGC1B

Target: PPARGC1B (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 beta (PPARGC1B))

Alternative Name: PPARGC1B

Background:

Synonyms: Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta)|PGC-1-related estrogen receptor alpha coactivator|PPARGC1B|PERC|PGC1|PGC1B|PPARGC1

Background: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1(NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Molecular Weight: 100-110 kDa

Gene ID: 133522

UniProt: Q86YN6

Pathways: AMPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha