PIEZO1 antibody (AA 2198-2431)

Catalog No. ABIN7117527

The Rabbit Polyclonal anti-PIEZO1 antibody (ABIN7117527) specifically detects PIEZO1 in WB, IHC and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PIEZO1 antibody (AA 2198-2431) (ABIN7117527)

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIEZO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PIEZO1 Antibody

Binding Specificity: AA 2198-2431

Purpose: PIEZO1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 2198-2431aa

Immunogen: family with sequence similarity 38, member A

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Alternative Name: PIEZO1

Background:

Synonyms: Piezo-type mechanosensitive ion channel component 1|Membrane protein induced by beta-amyloid treatment (Mib)|Protein FAM38A|PIEZO1|FAM38A|KIAA0233

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Molecular Weight: 250 kDa

Gene ID: 9780

UniProt: Q92508