RGS7 antibody

Catalog No. ABIN7118384

The Rabbit Polyclonal anti-RGS7 antibody has been validated for WB, ELISA and IHC. It is suitable to detect RGS7 in samples from Human, Mouse and Rat.

Quick Overview for RGS7 antibody (ABIN7118384)

Target: RGS7 (Regulator of G-Protein Signaling 7 (RGS7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RGS7 Antibody

Purpose: RGS7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: regulator of G-protein signaling 7

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RGS7

Target: RGS7 (Regulator of G-Protein Signaling 7 (RGS7))

Alternative Name: RGS7

Background:

Synonyms: Regulator of G-protein signaling 7 (RGS7)|RGS7

Background: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form(PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity(PubMed:10521509). May play a role in synaptic vesicle exocytosis(PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling(PubMed:15897264).

Molecular Weight: 62 kDa

Gene ID: 6000

UniProt: P49802

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling