RYK antibody

Catalog No. ABIN7118742

This anti-RYK antibody is a Rabbit Polyclonal antibody detecting RYK in WB, ELISA, IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for RYK antibody (ABIN7118742)

Target: RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RYK Antibody

Purpose: RYK antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RYK receptor-like tyrosine kinase

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RYK

Target: RYK (RYK Receptor-Like Tyrosine Kinase (RYK))

Alternative Name: RYK

Background:

Synonyms: Tyrosine-protein kinase RYK|RYK|JTK5A

Background: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Molecular Weight: 68 kDa

Gene ID: 6259

UniProt: P34925

Pathways: RTK Signaling, WNT Signaling, Regulation of Cell Size