SQSTM1 antibody (AA 1-440)

Catalog No. ABIN7118890

This Mouse Monoclonal antibody specifically detects SQSTM1 in WB, IHC, IF and ELISA. It exhibits reactivity toward Human.

Quick Overview for SQSTM1 antibody (AA 1-440) (ABIN7118890)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SQSTM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Clone: 5H3

Product Details anti-SQSTM1 Antibody

Binding Specificity: AA 1-440

Purpose: SQSTM1 antibody

Purification: protein A+G purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-440aa

Immunogen: sequestosome 1

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000 - 1:4000, IHC: 1:50 - 1:500, IF: 1:20 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Alternative Name: SQSTM1

Background:

Synonyms: Sequestosome-1|EBI3-associated protein of 60 kDa (EBIAP, p60)|Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|Ubiquitin-binding protein p62|SQSTM1|ORCA|OSIL

Background: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Molecular Weight: 62 kDa

Gene ID: 8878

UniProt: Q13501

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy