SREBF1 antibody

Catalog No. ABIN7119532

This Rabbit Polyclonal antibody specifically detects SREBF1 in WB, ELISA and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for SREBF1 antibody (ABIN7119532)

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SREBF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-SREBF1 Antibody

Purpose: SREBF1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: sterol regulatory element binding transcription factor 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SREBF1

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Alternative Name: SREBF1

Background:

Synonyms: Sterol regulatory element-binding protein 1 (SREBP-1)|Class D basic helix-loop-helix protein 1 (bHLHd1)|Sterol regulatory element-binding transcription factor 1|Processed sterol regulatory element-binding protein 1 Alternative names: Transcription factor SREBF1|SREBF1|BHLHD1|SREBP1

Background: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway(By similarity). Binds to the sterol regulatory element 1(SRE-1)(5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif(5'-ATCACGTGA-3') and to SRE-1(5'-ATCACCCCAC-3').

Molecular Weight: 125 kDa

Gene ID: 6720

UniProt: P36956

Pathways: AMPK Signaling, Caspase Cascade in Apoptosis, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha