SUV39H2 antibody

Catalog No. ABIN7119617

The Rabbit Polyclonal anti-SUV39H2 antibody is suitable to detect SUV39H2 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for SUV39H2 antibody (ABIN7119617)

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SUV39H2 Antibody

Purpose: SUV39H2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: suppressor of variegation 3-9 homolog 2(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SUV39H2

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Alternative Name: SUV39H2

Background:

Synonyms: Histone-lysine N-methyltransferase SUV39H2|Histone H3-K9 methyltransferase 2 (H3-K9-HMTase 2)|Lysine N-methyltransferase 1B|Suppressor of variegation 3-9 homolog 2 (Su(var)3-9 homolog 2)|SUV39H2|KMT1B

Background: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1(CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Molecular Weight: 53 kDa

Gene ID: 79723

UniProt: Q9H5I1