SYNGAP1 antibody

Catalog No. ABIN7119648

This anti-SYNGAP1 antibody is a Rabbit Polyclonal antibody detecting SYNGAP1 in WB, ELISA and IF. Suitable for Human, Mouse and Rat.

Quick Overview for SYNGAP1 antibody (ABIN7119648)

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNGAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-SYNGAP1 Antibody

Purpose: SYNGAP1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: synaptic Ras GTPase activating protein 1 homolog(rat)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SYNGAP1

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Alternative Name: SYNGAP1

Background:

Synonyms: Ras/Rap GTPase-activating protein SynGAP|Neuronal RasGAP|Synaptic Ras GTPase-activating protein 1 (Synaptic Ras-GAP 1)|SYNGAP1|KIAA1938

Background: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits(By similarity).

Molecular Weight: 148 kDa

Gene ID: 8831

UniProt: Q96PV0

Pathways: Regulation of long-term Neuronal Synaptic Plasticity