SYNGAP1 antibody

Catalog No. ABIN7270663

This Rabbit Monoclonal antibody specifically detects SYNGAP1 in WB. It exhibits reactivity toward Human.

Quick Overview for SYNGAP1 antibody (ABIN7270663)

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SYNGAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SYNGAP1 Antibody

Purpose: SynGAP Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human SynGAP

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SYNGAP1

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Alternative Name: SYNGAP1

Background: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016],MRD5, RASA1, RASA5, SYNGAP,Cell Type Marker,Cell Type Marker_Neuron marker,Cell Type Marker_Synapse marker,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Neuroscience,Signal Transduction,SYNGAP1

Molecular Weight: 147kDa

Gene ID: 8831

UniProt: Q96PV0

Pathways: Regulation of long-term Neuronal Synaptic Plasticity