TSPAN12 antibody

Catalog No. ABIN7119860

The Rabbit Polyclonal anti-TSPAN12 antibody is suitable to detect TSPAN12 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for TSPAN12 antibody (ABIN7119860)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSPAN12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TSPAN12 Antibody

Purpose: TSPAN12 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: tetraspanin 12

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Alternative Name: TSPAN12

Background:

Synonyms: Tetraspanin-12 (Tspan-12)|Tetraspan NET-2|Transmembrane 4 superfamily member 12|TSPAN12|NET2|TM4SF12

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Molecular Weight: 28 kDa

Gene ID: 23554

UniProt: O95859