TXNRD1 antibody

Catalog No. ABIN7119913

This Rabbit Polyclonal antibody specifically detects TXNRD1 in WB, IHC, ELISA, IP, IF and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TXNRD1 antibody (ABIN7119913)

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-TXNRD1 Antibody

Purpose: TXNRD1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: thioredoxin reductase 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:10-1:100, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TXNRD1

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: TXNRD1

Background:

Synonyms: Thioredoxin reductase 1, cytoplasmic (TR)|Gene associated with retinoic and interferon-induced mortality 12 protein (GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein)|KM-102-derived reductase-like factor|Peroxidase TXNRD1|Thioredoxin reductase TR1|TXNRD1|GRIM12|KDRF

Background: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

Molecular Weight: 54 kDa

Gene ID: 7296

UniProt: Q16881

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis