UBR2 antibody

Catalog No. ABIN7120484

The Rabbit Polyclonal anti-UBR2 antibody is suitable to detect UBR2 in samples from Human and Mouse. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for UBR2 antibody (ABIN7120484)

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UBR2 Antibody

Purpose: UBR2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin protein ligase E3 component n-recognin 2

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IF:1:10-1:100, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for UBR2

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Alternative Name: UBR2

Background:

Synonyms: E3 ubiquitin-protein ligase UBR2|N-recognin-2|RING-type E3 ubiquitin transferase UBR2|Ubiquitin-protein ligase E3-alpha-2|Ubiquitin-protein ligase E3-alpha-II|UBR2|C6orf133|KIAA0349

Background: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Molecular Weight: 66 kDa

Gene ID: 23304

UniProt: Q8IWV8