USP37 antibody

Catalog No. ABIN7120518

The Rabbit Polyclonal anti-USP37 antibody (ABIN7120518) specifically detects USP37 in ELISA and WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for USP37 antibody (ABIN7120518)

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP37 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-USP37 Antibody

Purpose: USP37 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 37

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for USP37

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Alternative Name: USP37

Background:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 37|Deubiquitinating enzyme 37|Ubiquitin thioesterase 37|Ubiquitin-specific-processing protease 37|USP37|KIAA1594

Background: Deubiquitinase that antagonizes the anaphase-promoting complex(APC/C) during G1/S transition by mediating deubiquitination of cyclin-A(CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A(CCNA1 and CCNA2).

Molecular Weight: 110 kDa, 70 kDa

Gene ID: 57695

UniProt: Q86T82