VTCN1 antibody

Catalog No. ABIN7120696

This Rabbit Polyclonal antibody specifically detects VTCN1 in WB, IHC and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for VTCN1 antibody (ABIN7120696)

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VTCN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-VTCN1 Antibody

Purpose: VTCN1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: V-set domain containing T cell activation inhibitor 1

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for VTCN1

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Alternative Name: VTCN1

Background:

Synonyms: V-set domain-containing T-cell activation inhibitor 1|B7 homolog 4 (B7-H4)|B7h.5|Immune costimulatory protein B7-H4|Protein B7S1|T-cell costimulatory molecule B7x|VTCN1|B7H4

Background: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Molecular Weight: 50-80 kDa

Gene ID: 79679

UniProt: Q7Z7D3