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MEF2B antibody

This Mouse Monoclonal antibody specifically detects MEF2B in WB, IF, FACS and IP. It exhibits reactivity toward Human.
Catalog No. ABIN7126157

Quick Overview for MEF2B antibody (ABIN7126157)

Target

See all MEF2B Antibodies
MEF2B (Myocyte Enhancer Factor 2B (MEF2B))

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This MEF2B antibody is un-conjugated

Application

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Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)
  • Specificity

    The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.

    Cross-Reactivity (Details)

    Human.

    Purification

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    Recombinant full-length human MEF2B protein

    Isotype

    IgG2a
  • Application Notes

    Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein), Western Blot (1-2 μg/mL),Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or Ramos cells.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Preservative

    Azide free

    Storage

    -20 °C,-80 °C

    Storage Comment

    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Expiry Date

    24 months
  • Target

    MEF2B (Myocyte Enhancer Factor 2B (MEF2B))

    Alternative Name

    MEF2B

    Background

    MADS box transcription enhancer factor 2, MDS1 EVI1, Mef2b, Myocyte enhancer factor 2B, Myocyte-specific enhancer factor 2B, PRDM3, RSRFR2, Serum response factor like protein 2, XMEF2,MEF2B (Transcriptional Activator)
    Cellular localisation: Nucleus.

    Molecular Weight

    160kDa

    Gene ID

    100271849, 4207, 153629

    UniProt

    Q02080
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