Endoglin antibody

Catalog No. ABIN7126335

The Mouse Monoclonal anti-Endoglin antibody has been validated for FACS, ELISA, IF, Func and Coat. It is suitable to detect Endoglin in samples from Human.

Quick Overview for Endoglin antibody (ABIN7126335)

Target: Endoglin (ENG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Functional Studies (Func), Coating (Coat)

Product Details anti-Endoglin Antibody

Specificity: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Cross-Reactivity (Details): Human, Monkey, Horse, Pig and Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)

Isotype: IgG1

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), Functional Assays (order antibody without BSA and azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (2-4 μg/mL) Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, A431 or HL-60 cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: ENG

Background: CD105, END, Endoglin, Eng, HHT1, S-endoglin,Endoglin / CD105 (Angiogenesis Marker)
Cellular localisation: Cell Surface

Molecular Weight: 80kDa (Monomer), 160kDa (Homodimer)

Gene ID: 2022, 76753

UniProt: P17813