FGF21 antibody (AA 91-209)

Catalog No. ABIN7126464

The Mouse Monoclonal anti-FGF21 antibody is suitable to detect FGF21 in samples from Human. It has been validated for IHC.

Quick Overview for FGF21 antibody (AA 91-209) (ABIN7126464)

Target: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGF21 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: FGF21-3691

Product Details anti-FGF21 Antibody

Binding Specificity: AA 91-209

Purpose: FGF21 (Fibroblast growth factor 21) Antibody

Specificity: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10-FGF-23. Members of the FGF family share 30-55 % amino acid sequence identity and similar gene structure and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 91-209) of human FGF21 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human kidney or breast cancer.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for FGF21

Target: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Alternative Name: FGF21

Background:

FGFL, PRO10196

Human kidney or breast cancer.

Molecular Weight: 22kDa

Gene ID: 26291, 283015

UniProt: Q9NSA1

Pathways: RTK Signaling