FERMT1 antibody (AA 216-677)
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- Target See all FERMT1 Antibodies
- FERMT1 (Fermitin Family Member 1 (FERMT1))
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Binding Specificity
- AA 216-677
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This FERMT1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- Kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) is an important component of cell-extracellular matrix adhesion. Kindlin-1 is involved in cell adhesion, possibly via its interaction with integrins and may mediate TGF-beta 1 signaling during tumor progression. Kindlin-1 has been shown to be significantly upregulated in lung and colon carcinomas. Mutations in the kindlin-1 gene, FERMT1, causes Kindler syndrome. Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal pigmentation and fragility of the skin. We have developed monoclonal anti-kidlin-1 antibodies. This monoclonal antibody recognizes kindlin-1 in multiple assays including Western blotting, immunoprecipitation, immunohistochemical and immunofluorescent staining.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant protein containing Kindlin-1 (residues 216-677)
- Isotype
- IgG2a
- Top Product
- Discover our top product FERMT1 Primary Antibody
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- Application Notes
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Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: 293T whole cell lysate. Human tonsil or liver.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- FERMT1 (Fermitin Family Member 1 (FERMT1))
- Alternative Name
- FERMT1 (FERMT1 Products)
- Synonyms
- C20orf42 antibody, DTGCU2 antibody, KIND1 antibody, UNC112A antibody, URP1 antibody, 5830467P10Rik antibody, Kindlin-1 antibody, RGD1306816 antibody, si:ch73-22c10.1 antibody, wu:fc32b07 antibody, fermitin family member 1 antibody, fermitin family member 1 S homeolog antibody, fermitin family homolog 1 antibody, FERMT1 antibody, Fermt1 antibody, fermt1.S antibody, fermt1 antibody, LOC100548276 antibody
- Background
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Fermitin family homolog 1 (Fermt1), Kindlin-1 (KIND1), Kindlerin, Unc-112, UNC112A, URP1, DTGCU2,Kindlin-1 / KIND1
Cellular localisation: Cytoplasm. - Molecular Weight
- 77kDa
- Gene ID
- 55612, 472054
- UniProt
- Q9BQL6
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