Recombinant PARVG antibody

Catalog No. ABIN7126931

Product Details anti-PARVG Antibody

Target: PARVG (Parvin, gamma (PARVG))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PARVG antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: The parvin family, including i±-parvin, i²-parvin and i³-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, i±-actinin and testicular kinase 1. i±-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of i±-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. i²-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-i³-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotype: IgG

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for PARVG

Target: PARVG (Parvin, gamma (PARVG))

Alternative Name: PARVG (PARVG Products)

Synonyms: PARVG antibody, AI413459 antibody, parvin gamma antibody, parvin gamma S homeolog antibody, parvin, gamma antibody, PARVG antibody, parvg.S antibody, Parvg antibody

Background: Gamma parvin, PARVG,Gamma-parvin (PARVG)
Cellular localisation: Cytoplasm. Cell Surface.

Molecular Weight: 37kDa

Gene ID: 64098

UniProt: Q9HBI0