PARVG antibody

Catalog No. ABIN7861900

The Mouse Monoclonal anti-PARVG antibody (Clone 8C5-2) (ABIN7861900) specifically detects PARVG in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for PARVG antibody (ABIN7861900)

Target: PARVG (Parvin, gamma (PARVG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARVG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 8C5-2

Product Details anti-PARVG Antibody

Purpose: Gamma-parvin Antibody

Specificity: The parvin family, including °™-parvin, æ-parvin and Á-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, °™-actinin and testicular kinase 1. °™-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of °™-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. æ-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-Á-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for PARVG

Target: PARVG (Parvin, gamma (PARVG))

Alternative Name: Gamma-parvin

Background:

Gamma parvin, PARVG

Jurkat cells. Human tonsil or stomach.

Molecular Weight: 37kDa

Gene ID: 64098

UniProt: Q9HBI0