Recombinant APOC3 antibody

Catalog No. ABIN7127343

The Rabbit Monoclonal anti-APOC3 antibody has been validated for ELISA and IHC. It is suitable to detect APOC3 in samples from Human.

Quick Overview for Recombinant APOC3 antibody (ABIN7127343)

Target: APOC3 (Apolipoprotein C-III (APOC3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This APOC3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 8H12

Product Details anti-APOC3 Antibody

Purpose: APOC3 Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human APOC3

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for APOC3

Target: APOC3 (Apolipoprotein C-III (APOC3))

Alternative Name: APOC3

Background:

Background: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion, extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).

Aliases: Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3), APOC3

UniProt: P02656

Pathways: Carbohydrate Homeostasis, Lipid Metabolism