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Recombinant ITGA4 antibody

This Rabbit Monoclonal antibody specifically detects ITGA4 in WB and ELISA. It exhibits reactivity toward Human.
Catalog No. ABIN7127576

Quick Overview for Recombinant ITGA4 antibody (ABIN7127576)

Target

See all ITGA4 Antibodies
ITGA4 (Integrin alpha 4 (ITGA4))

Antibody Type

Recombinant Antibody

Reactivity

  • 136
  • 65
  • 31
  • 10
  • 10
  • 9
  • 8
  • 7
  • 6
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 75
  • 58
  • 27
Rabbit

Clonality

  • 99
  • 62
  • 2
Monoclonal

Conjugate

  • 90
  • 13
  • 11
  • 10
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
This ITGA4 antibody is un-conjugated

Application

  • 83
  • 49
  • 43
  • 40
  • 36
  • 20
  • 16
  • 11
  • 6
  • 6
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA

Clone

1H4
  • Cross-Reactivity

    Human

    Purification

    Affinity-chromatography

    Immunogen

    A synthesized peptide derived from human Integrin alpha 4

    Isotype

    IgG
  • Application Notes

    Recommended dilution: WB:1:500-1:5000,

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    ITGA4 (Integrin alpha 4 (ITGA4))

    Alternative Name

    ITGA4

    Background

    Background: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

    Aliases: Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d), ITGA4, CD49D

    UniProt

    P13612

    Pathways

    Integrin Complex
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