MDM4-binding Protein antibody (pSer367)

Catalog No. ABIN7138576

This anti-MDM4-binding Protein antibody is a Rabbit Polyclonal antibody detecting MDM4-binding Protein in WB, ELISA and IHC. Suitable for Human.

Quick Overview for MDM4-binding Protein antibody (pSer367) (ABIN7138576)

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDM4-binding Protein antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MDM4-binding Protein Antibody

Binding Specificity: pSer367

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 367 (T-I-S(p)-A-P) derived from Human MDM4.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Alternative Name: MDM4

Background:

Background: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Aliases: DKFZp781B1423 antibody, Double minute 4 antibody, Double minute 4 human homolog of p53 binding protein antibody, Double minute 4 protein antibody, HDMX antibody, MDM 4 antibody, Mdm2 like p53 binding protein antibody, Mdm2-like p53-binding protein antibody, MDM4 antibody, Mdm4 p53 binding protein homolog mouse antibody, Mdm4 protein antibody, MDM4 related protein 1 antibody, Mdm4 transformed 3T3 cell double minute 4 antibody, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein antibody, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse antibody, MDM4_HUMAN antibody, Mdmx protein antibody, MGC132766 antibody, Mouse double minute 4 homolog antibody, Mouse double minute 4 human homolog of p53 binding protein antibody, MRP 1 antibody, MRP1 antibody, p53 binding protein antibody, p53 BINDING PROTEIN MDM4 antibody, p53-binding protein Mdm4 antibody, Protein Mdm4 antibody, Protein Mdmx antibody

UniProt: O15151

Pathways: Cell Division Cycle