BIM antibody (pSer69)

Catalog No. ABIN7138680

The Rabbit Polyclonal anti-BIM antibody is suitable to detect BIM in samples from Human. It has been validated for IHC, ELISA and IF.

Quick Overview for BIM antibody (pSer69) (ABIN7138680)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIM antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-BIM Antibody

Binding Specificity: pSer69

Purpose: Phospho-BCL2L11 (Ser69) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name: BCL2L11

Background:

Background: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis

Fukazawa H, et al. (2004) Mol Cancer Ther , 3(10): 1281-1288
Luciano F, et al. (2003) Oncogene , 22(43): 6785-6793

Aliases: BCL2 like 11 antibody, B2L11_HUMAN antibody, BAM antibody, Bcl 2 interacting protein Bim antibody, Bcl 2 related ovarian death agonist antibody, Bcl-2-like protein 11 antibody, BCL2 interacting mediator of cell death antibody, BCL2 like 11 (apoptosis facilitator) antibody, BCL2 like protein 11 antibody, Bcl2-interacting mediator of cell death antibody, Bcl2-L-11 antibody, Bcl2l11 antibody, BIM alpha6 antibody, BIM antibody, BIM beta6 antibody, BIM beta7 antibody, BimEL antibody, BimL antibody, BOD antibody

UniProt: O43521

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity