JNK2 antibody (pThr183)

Catalog No. ABIN7138785

The Rabbit Polyclonal anti-JNK2 antibody is suitable to detect JNK2 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for JNK2 antibody (pThr183) (ABIN7138785)

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JNK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-JNK2 Antibody

Binding Specificity: pThr183

Purpose: Phospho-MAPK9/MAPK10 (Thr183) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 183 (M-M-T(p)-P-Y) derived from Human SAPK/JNK.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for JNK2

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Alternative Name: MAPK9

Background:

Background:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.

Ferrer, et al. (2003) Neuropathology & Applied Neurobiology 29: 23
Zhonghong Guan, et al. (1999) J Biol Chem, Vol. 274: 36200-36206
D.Margriet Ouwens1, et al. (2002)The EMBO Journal 21: 3782

Aliases: c Jun kinase 2 antibody; C Jun N terminal kinase 2 antibody; c-Jun N-terminal kinase 2 antibody; JNK 55 antibody; JNK-55 antibody; JNK2 alpha antibody; JNK2 antibody; JNK2 beta antibody; JNK2A antibody; JNK2alpha antibody; JNK2B antibody; JNK2BETA antibody; Jun kinase antibody; MAP kinase 9 antibody; MAPK 9 antibody; Mapk9 antibody; Mitogen activated protein kinase 9 antibody; Mitogen-activated protein kinase 9 antibody; MK09_HUMAN antibody; P54a antibody; p54aSAPK antibody; PRKM9 antibody; Protein kinase, mitogen-activated, 9 antibody; SAPK alpha antibody; SAPK antibody; SAPK1a antibody; Stress activated protein kinase 1a antibody; Stress-activated protein kinase JNK2 antibody

UniProt: P45984

Pathways: MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins