Aurora Kinase C antibody (pThr202, pThr236)

Catalog No. ABIN7138814

This Rabbit Polyclonal antibody specifically detects Aurora Kinase C in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for Aurora Kinase C antibody (pThr202, pThr236) (ABIN7138814)

Target: Aurora Kinase C (AURKC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-Aurora Kinase C Antibody

Binding Specificity: pThr202, pThr236

Purpose: Phospho-AURKC (Thr236/202) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 236/202 (C-G-T(p)-L-D) derived from Human AurB/C.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: AURKC

Background:

Background: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Aliases: AURKC antibody, AIE 2 antibody, Aie1 antibody, AIE2 antibody, AIK 3 antibody, AIK3 antibody, ARK 3 antibody, ARK-3 antibody, ARK3 antibody, Aur C antibody, AurC antibody, Aurkc antibody, AURKC_HUMAN antibody, aurora 3 antibody, Aurora C antibody, Aurora kinase C antibody, aurora related kinase 3 antibody, Aurora-related kinase 3 antibody, Aurora/Ipl1 related kinase 3 antibody, Aurora/Ipl1-related kinase 3 antibody, Aurora/Ipl1/Eg2 protein 2 antibody, EC 2.7.11.1 antibody, Serine threonine protein kinase 13 antibody, serine/threonine kinase 13 (aurora/IPL1 like) antibody, serine/threonine protein kinase aurora C antibody, Serine/threonine-protein kinase 13 antibody, Serine/threonine-protein kinase aurora-C antibody, SPGF5 antibody, STK13 antibody

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location