APP antibody (pThr668, pThr743)

Catalog No. ABIN7138900

This anti-APP antibody is a Rabbit Polyclonal antibody detecting APP in WB, ELISA, IHC and IF. Suitable for Human.

Quick Overview for APP antibody (pThr668, pThr743) (ABIN7138900)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-APP Antibody

Binding Specificity: pThr668, pThr743

Purpose: Phospho-APP (Thr743/668) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid beta A4.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: APP

Background:

Background: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., Oct 2003, 163: 83.Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006, 11: 633 - 645Keun-A Chang, Mol. Cell. Biol., Jun 2006, 26: 4327 ?C 4338.Thor D. Stein J. Neurosci., Sep 2004, 24: 7707 - 7717

Aliases: A4 antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID(50) antibody, AID(57) antibody, AID(59) antibody, Alzheimer disease amyloid protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, APP antibody, APPI antibody, Beta amyloid protein 42 antibody, Beta APP42 antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebral vascular amyloid peptide antibody, CVAP antibody, Gamma-CTF(50) antibody, Gamma-CTF(57) antibody, Gamma-CTF(59) antibody, PN-II antibody, PreA4 antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour