IGF1R antibody (pTyr1346)

Catalog No. ABIN7138933

This anti-IGF1R antibody is a Rabbit Polyclonal antibody detecting IGF1R in IHC and ELISA. Suitable for Human.

Quick Overview for IGF1R antibody (pTyr1346) (ABIN7138933)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1R antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-IGF1R Antibody

Binding Specificity: pTyr1346

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R .

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF1R

Background:

Background:

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Ullrich A., EMBO J. 5:2503-2512(1986).
Abbot A.M., J. Biol. Chem. 267:10759-10763(1992).
The MGC Project Team,Genome Res. 14:2121-2127(2004).

Aliases: CD221 antibody, CD221 antigen antibody, IGF 1 receptor antibody, IGF 1R antibody, IGF I receptor antibody, IGF-I receptor antibody, Igf1r antibody, IGF1R_HUMAN antibody, IGFIR antibody, IGFIRC antibody, IGFR antibody, Insulin like growth factor 1 receptor antibody, Insulin like growth factor 1 receptor precursor antibody, Insulin-like growth factor 1 receptor beta chain antibody, Insulin-like growth factor I receptor antibody, JTK13 antibody, MGC142170 antibody, MGC142172 antibody, MGC18216 antibody, Soluble IGF1R variant 1 antibody, Soluble IGF1R variant 2 antibody

UniProt: P08069

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy