Phospholipase D2 antibody (pTyr169)

Catalog No. ABIN7138945

The Rabbit Polyclonal anti-Phospholipase D2 antibody (ABIN7138945) specifically detects Phospholipase D2 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for Phospholipase D2 antibody (pTyr169) (ABIN7138945)

Target: Phospholipase D2 (PLD2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase D2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Phospholipase D2 Antibody

Binding Specificity: pTyr169

Purpose: Phospho-PLD2 (Tyr169) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 169(E-N-Y(p)-L-N) derived from Human PLD2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Phospholipase D2

Target: Phospholipase D2 (PLD2)

Alternative Name: PLD2

Background:

Background:

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.

Steed P.M., FASEB J. 12:1309-1317(1998).
Lopez I., J. Biol. Chem. 273:12846-12852(1998).
Divecha N., EMBO J. 19:5440-5449(2000).

Aliases: Choline phosphatase 2 antibody, EC 3.1.4.4 antibody, hPLD 2 antibody, hPLD2 antibody, mPLD2 antibody, Phosphatidylcholine hydrolyzing phospholipase D2 antibody, Phosphatidylcholine-hydrolyzing phospholipase D2 antibody, Phospholipase D2 antibody, PhospholipaseD2 antibody, PLD 2 antibody, PLD1C antibody, Pld2 antibody, PLD2_HUMAN antibody, Pldc antibody, rPLD2 antibody

UniProt: O14939

Pathways: RTK Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling