MUSK antibody (pTyr755)

Catalog No. ABIN7139062

This anti-MUSK antibody is a Rabbit Polyclonal antibody detecting MUSK in WB and ELISA. Suitable for Human.

Quick Overview for MUSK antibody (pTyr755) (ABIN7139062)

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUSK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MUSK Antibody

Binding Specificity: pTyr755

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK .

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MUSK

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Alternative Name: MUSK

Background:

Background:

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

Valenzuela D.M., Neuron 15:573-584(1995).
Humphray S.J., Nature 429:369-374(2004).
Bergamin E., Mol. Cell 39:100-109(2010).

Aliases: CMS9 antibody, FADS antibody, MDK 4 antibody, MDK4 antibody, MGC126323 antibody, MGC126324 antibody, Muscle antibody, Muscle associated receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine protein kinase antibody, Muscle specific kinase receptor antibody, Muscle specific tyrosine kinase receptor antibody, Muscle specific tyrosine protein kinase receptor antibody, Muscle-specific kinase receptor antibody, Muscle-specific tyrosine-protein kinase receptor antibody, MuSK antibody, MUSK_HUMAN antibody, Neural fold somite kinase 1 antibody, Neural fold somite kinase 2 antibody, Neural fold somite kinase 3 antibody, Neural fold somite kinase1 antibody, Neural fold somite kinase2 antibody, Neural fold somite kinase3 antibody, Nsk 1 antibody, Nsk 2 antibody, Nsk 3 antibody, Nsk1 antibody, Nsk2 antibody, Nsk3 antibody, Receptor tyrosine kinase MuSK antibody, Skeletal muscle receptor tyrosine kinase antibody, skeletal receptor tyrosine-protein kinase antibody

UniProt: O15146

Pathways: RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development