TBK1 antibody (AA 644-661) (HRP)

Catalog No. ABIN7140133

This anti-TBK1 antibody is a Rabbit Polyclonal antibody detecting TBK1 in ELISA. Suitable for Human.

Quick Overview for TBK1 antibody (AA 644-661) (HRP) (ABIN7140133)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBK1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-TBK1 Antibody (HRP)

Binding Specificity: AA 644-661

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Peptide sequence from Human Serine/threonine-protein kinase TBK1 protein (644-661AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: TBK1

Background:

Background: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on \'Ser-177\', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).

Aliases: EC 2.7.11.1 antibody, FLJ11330 antibody, FTDALS4 antibody, NAK antibody, NF kappa B activating kinase antibody, NF kB activating kinase antibody, NF-kappa-B-activating kinase antibody, Serine/threonine protein kinase TBK 1 antibody, Serine/threonine protein kinase TBK1 antibody, Serine/threonine-protein kinase TBK1 antibody, T2K antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, TBK 1 antibody, Tbk1 antibody, TBK1_HUMAN antibody

UniProt: Q9UHD2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome