14-3-3 sigma/SFN antibody (AA 1-248)

Catalog No. ABIN7142099

Product Details anti-14-3-3 sigma/SFN Antibody

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Binding Specificity: AA 1-248

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 14-3-3 sigma/SFN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 14-3-3 protein sigma protein (1-248AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for 14-3-3 sigma/SFN

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Alternative Name: SFN (SFN Products)

Synonyms: YWHAS antibody, Er antibody, Mme1 antibody, Ywhas antibody, stratifin antibody, SFN antibody, Sfn antibody

Background:

Background: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

Aliases: 14 3 3 protein sigma antibody, 14-3-3 protein sigma antibody, 1433S_HUMAN antibody, Epithelial cell marker protein 1 antibody, Er antibody, HME 1 antibody, HME1 antibody, MGC143283 antibody, Mkrn3 antibody, Mme1 antibody, OTTHUMP00000004242 antibody, RP23 137L22.11 antibody, SFN antibody, SFN protein antibody, Stratifin antibody, YWHAS antibody

UniProt: P31947

Pathways: p53 Signaling, Myometrial Relaxation and Contraction