ANAPC2 antibody (AA 1-230)

Catalog No. ABIN7144072

Product Details anti-ANAPC2 Antibody

Target: ANAPC2 (Anaphase Promoting Complex Subunit 2 (ANAPC2))

Binding Specificity: AA 1-230

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Anaphase-promoting complex subunit 2 protein (1-230AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ANAPC2

Target: ANAPC2 (Anaphase Promoting Complex Subunit 2 (ANAPC2))

Alternative Name: ANAPC2 (ANAPC2 Products)

Synonyms: anapc2 antibody, ANAPC2 antibody, DDBDRAFT_0203816 antibody, DDBDRAFT_0234264 antibody, DDB_0203816 antibody, DDB_0234264 antibody, si:ch73-203i15.5 antibody, APC2 antibody, RP11-350O14.5 antibody, 9230107K09Rik antibody, AL024279 antibody, Apc2 antibody, Emi4 antibody, Imi4 antibody, mKIAA1406 antibody, F28I8.30 antibody, F28I8_30 antibody, anaphase-promoting complex/cyclosome 2 antibody, anaphase promoting complex subunit 2 antibody, anaphase promoting complex subunit 2 L homeolog antibody, anaphase-promoting complex/cyclosome 2 antibody, Anaphase-promoting complex subunit 2 antibody, ANAPC2 antibody, anapc2.L antibody, anapc2 antibody, Anapc2 antibody, APC2 antibody, apc-2 antibody

Background:

Background: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of \\\'Lys-11\\\'-linked polyubiquitin chains and, to a lower extent, the formation of \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Aliases: anapc2 antibody, Anaphase promoting complex subunit 2 antibody, Anaphase-promoting complex subunit 2 antibody, ANC2_HUMAN antibody, APC2 antibody, Cyclosome subunit 2 antibody, KIAA1406 antibody, OTTHUMP00000022692 antibody, RP11 350O14.5 antibody

UniProt: Q9UJX6

Pathways: Regulation of Cell Size