AGT antibody (AA 44-427)

Catalog No. ABIN7144136

This Rabbit Polyclonal antibody specifically detects AGT in WB, IHC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for AGT antibody (AA 44-427) (ABIN7144136)

Target: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-AGT Antibody

Binding Specificity: AA 44-427

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Angiotensinogen protein (44-427AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AGT

Target: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Alternative Name: AGT

Background:

Background: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Aliases: Aangiotensinogen (serpin peptidase inhibitor clade A member 8) antibody, AGT antibody, AI265500 antibody, Alpha 1 antiproteinase antitrypsin antibody, Ang antibody, Ang I antibody, Ang II antibody, Ang III antibody, AngII antibody, Angiotensin I antibody, Angiotensin II antibody, Angiotensin III antibody, Angiotensin-3 antibody, Angiotensinogen (PAT) antibody, Angiotensinogen antibody, ANGT_HUMAN antibody, ANHU antibody, ANRT antibody, AT-2 antibody, AT-II antibody, Des-Asp[1]-angiotensin II antibody, FLJ92595 antibody, FLJ97926 antibody, MGC105326 antibody, PAT antibody, Pre angiotensinogen antibody, Serine (or cysteine) proteinase inhibitor antibody, Serpin A8 antibody, Serpin peptidase inhibitor clade A member 8 antibody, SERPINA8 antibody

UniProt: P01019

Pathways: JAK-STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity