TAP1 antibody (AA 524-808)

Catalog No. ABIN7144328

This Rabbit Polyclonal antibody specifically detects TAP1 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TAP1 antibody (AA 524-808) (ABIN7144328)

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-TAP1 Antibody

Binding Specificity: AA 524-808

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Antigen peptide transporter 1 protein (524-808AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TAP1

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Alternative Name: TAP1

Background:

Background: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Aliases: ABC 17 antibody, ABC transporter MHC 1 antibody, ABC17 antibody, ABCB 2 antibody, ABCB2 antibody, Antigen peptide transporter 1 antibody, APT 1 antibody, APT1 antibody, ATP binding cassette sub family B (MDR/TAP) member 2 antibody, ATP binding cassette sub family B member 2 antibody, ATP binding cassette transporter antibody, ATP-binding cassette sub-family B member 2 antibody, D6S114E antibody, FLJ26666 antibody, FLJ41500 antibody, Peptide supply factor 1 antibody, Peptide transporter involved in antigen processing 1 antibody, Peptide transporter PSF 1 antibody, Peptide transporter PSF1 antibody, Peptide transporter TAP 1 antibody, Peptide transporter TAP1 antibody, PSF 1 antibody, PSF-1 antibody, PSF1 antibody, Really interesting new gene 4 protein antibody, RING 4 antibody, RING4 antibody, TAP 1 antibody, TAP1 antibody, TAP1*0102N antibody, TAP1_HUMAN antibody, TAP1N antibody, Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody, Transporter 1 ATP binding cassette sub family B antibody, Transporter associated with antigen processing antibody, Transporter ATP binding cassette major histocompatibility complex 1 antibody, Y3 antibody

UniProt: Q03518

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response