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CALHM1 antibody (AA 202-346)

CALHM1 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7146296
  • Target See all CALHM1 Antibodies
    CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
    Binding Specificity
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 202-346
    Reactivity
    • 23
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CALHM1 antibody is un-conjugated
    Application
    • 22
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA)
    Isotype
    IgG
    Top Product
    Discover our top product CALHM1 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
    Alternative Name
    CALHM1 (CALHM1 Products)
    Synonyms
    FAM26C antibody, Fam26c antibody, RGD1564891 antibody, EG546729 antibody, calcium homeostasis modulator 1 antibody, novel protein similar to vertebrate calcium homeostasis modulator protein family antibody, CALHM1 antibody, LOC557535 antibody, Calhm1 antibody
    Background

    Background: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.

    Aliases: CAHM1_HUMAN antibody, Calcium homeostasis modulator 1 antibody, Calcium homeostasis modulator protein 1 antibody, CALHM1 antibody, FAM26C antibody, Family with sequence similarity 26, member C antibody, MGC39514 antibody, MGC39617 antibody, OTTHUMP00000020413 antibody, Protein FAM26C antibody

    UniProt
    Q8IU99
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