CALHM1 antibody (N-Term)

Catalog No. ABIN6991269

The Rabbit Polyclonal anti-CALHM1 antibody (ABIN6991269) specifically detects CALHM1 in WB, ELISA, IF and IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for CALHM1 antibody (N-Term) (ABIN6991269)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALHM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CALHM1 Antibody

Binding Specificity: AA 60-110, N-Term

Purification: CALHM1 Antibody is affinity chromatography purified via peptide column.

Immunogen: CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1.

Isotype: IgG

Application Details

Application Notes: CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CALHM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CALHM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Alternative Name: CALHM1

Background: CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Gene ID: 255022

NCBI Accession: NP_001001412

UniProt: Q8IU99