CEP290 antibody (AA 86-156)

Catalog No. ABIN7147403

This Rabbit Polyclonal antibody specifically detects CEP290 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for CEP290 antibody (AA 86-156) (ABIN7147403)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CEP290 Antibody

Binding Specificity: AA 86-156

Purpose: CEP290 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Centrosomal protein of 290 kDa protein (86-156AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background:

Background: Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May act as a gatekeeper to control entry of the BBSome complex to cilia (PubMed:25552655). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes (By similarity). Activates ATF4-mediated transcription (PubMed:16682973).

Aliases: 3H11AG antibody, Bardet-Biedl syndrome 14 protein antibody, BBS14 antibody, Cancer/testis antigen 87 antibody, CE290_HUMAN antibody, Centrosomal protein 290 antibody, Centrosomal protein 290 kDa antibody, Centrosomal protein of 290 kDa antibody, Cep290 antibody, CT87 antibody, CTCL tumor antigen se2 2 antibody, FLJ13615 antibody, FLJ21979 antibody, JBTS5 antibody, JBTS6 antibody, KIAA0373 antibody, LCA10 antibody, Meckel syndrome, type 4 antibody, MKS4 antibody, Monoclonal antibody 3H11 antigen antibody, Nephrocystin 6 antibody, Nephrocystin-6 antibody, NPHP6 antibody, POC3 antibody, POC3 centriolar protein homolog antibody, Prostate cancer antigen T21 antibody, rd16 antibody, SLSN6 1, 2, 5 antibody, SLSN6 antibody, Tumor antigen se2-2 antibody

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase