CBX3 antibody (AA 10-122) (Biotin)

Catalog No. ABIN7147702

This anti-CBX3 antibody is a Rabbit Polyclonal antibody detecting CBX3 in ELISA. Suitable for Human.

Quick Overview for CBX3 antibody (AA 10-122) (Biotin) (ABIN7147702)

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CBX3 Antibody (Biotin)

Binding Specificity: AA 10-122

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Chromobox protein homolog 3 protein (10-122AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Alternative Name: CBX3

Background:

Background: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at \'Lys-9\', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 \'Lys-9\' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Aliases: CBX 3 antibody, CBX3 antibody, CBX3_HUMAN antibody, Chromobox homolog 3 (HP1 gamma homolog, Drosophila) antibody, Chromobox homolog 3 antibody, Chromobox protein homolog 3 antibody, GAMMA antibody, HECH antibody, Heterochromatin like protein 1 antibody, Heterochromatin protein 1 homolog gamma antibody, Heterochromatin protein HP1 gamma antibody, HP1 gamma antibody, HP1 gamma homolog antibody, HP1Hs gamma antibody, Modifier 2 protein antibody

UniProt: Q13185