CYP1A2 antibody (AA 268-445)

Catalog No. ABIN7149206

This Rabbit Polyclonal antibody specifically detects CYP1A2 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for CYP1A2 antibody (AA 268-445) (ABIN7149206)

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP1A2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-CYP1A2 Antibody

Binding Specificity: AA 268-445

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytochrome P450 1A2 protein (268-445AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CYP1A2

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Alternative Name: CYP1A2

Background:

Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.

Aliases: Aryl hydrocarbon hydroxylase antibody, CP 12 antibody, CP12 antibody, CP1A2_HUMAN antibody, CYP1A2 antibody, CYPIA2 antibody, Cytochrome P(3)450 antibody, Cytochrome P450 1A2 antibody, Cytochrome P450 4 antibody, Cytochrome P450 family 1 polypeptide 2 antibody, Cytochrome P450 family 1 subfamily A polypeptide 2 antibody, Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody, Cytochrome P450-P3 antibody, Cytochrome P4501A2 antibody, Dioxin inducable P3 450 antibody, Flavoprotein linked monooxygenase antibody, Flavoprotein-linked monooxygenase antibody, Microsomal monooxygenase antibody, P(3)450 antibody, P3 450 antibody, P450 4 antibody, P450 form 4 antibody, P450 P3 antibody, P450(PA) antibody, Xenobiotic monooxygenase antibody

UniProt: P05177