POLI antibody (AA 458-711) (Biotin)

Catalog No. ABIN7150252

This anti-POLI antibody is a Rabbit Polyclonal antibody detecting POLI in ELISA. Suitable for Human.

Quick Overview for POLI antibody (AA 458-711) (Biotin) (ABIN7150252)

Target: POLI (Polymerase (DNA Directed) iota (POLI))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLI antibody is conjugated to Biotin

Application: ELISA

Product Details anti-POLI Antibody (Biotin)

Binding Specificity: AA 458-711

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA polymerase iota protein (458-711AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for POLI

Target: POLI (Polymerase (DNA Directed) iota (POLI))

Alternative Name: POLI

Background:

Background: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5\'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Aliases: DNA polymerase iota antibody, Eta 2 antibody, Eta2 antibody, POLI antibody, POLI_HUMAN antibody, Polymerase (DNA directed) iota antibody, RAD 30B antibody, RAD30 homolog B antibody, RAD30, S. cerevisiae, homolog of antibody, RAD30B antibody, RAD3OB antibody

UniProt: Q9UNA4

Pathways: DNA Damage Repair