MAP2K7 antibody (AA 17-160) (Biotin)

Catalog No. ABIN7150726

This anti-MAP2K7 antibody is a Rabbit Polyclonal antibody detecting MAP2K7 in ELISA. Suitable for Human.

Quick Overview for MAP2K7 antibody (AA 17-160) (Biotin) (ABIN7150726)

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K7 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MAP2K7 Antibody (Biotin)

Binding Specificity: AA 17-160

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dual specificity mitogen-activated protein kinase kinase 7 protein (17-160AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAP2K7

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Alternative Name: MAP2K7

Background:

Background: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Aliases: c-Jun N-terminal kinase kinase 2 antibody, Dual specificity mitogen activated protein kinase kinase 7 antibody, Dual specificity mitogen-activated protein kinase kinase 7 antibody, JNK activating kinase 2 antibody, JNK kinase 2 antibody, JNK-activating kinase 2 antibody, JNKK 2 antibody, Jnkk-2 antibody, Jnkk2 antibody, MAP kinase kinase 7 antibody, MAP2K7 antibody, MAPK/ERK kinase 7 antibody, MAPKK 7 antibody, MAPKK-7 antibody, MAPKK7 antibody, MEK 7 antibody, Mitogen Activated Protein Kinase kinase 7 antibody, MKK 7 antibody, MKK-7 antibody, MKK7 antibody, MP2K7_HUMAN antibody, PRKMK 7 antibody, PRKMK-7 antibody, PRKMK7 antibody, SAPK kinase 4 antibody, SAPKK-4 antibody, SAPKK4 antibody, Sek 2 antibody, Sek-2 antibody, Sek2 antibody, SKK4 antibody, stress-activated protein kinase kinase 4 antibody

UniProt: O14733

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling