PIAS2 antibody (AA 1-572)

Catalog No. ABIN7150964

This Rabbit Polyclonal antibody specifically detects PIAS2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for PIAS2 antibody (AA 1-572) (ABIN7150964)

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS2 antibody is un-conjugated

Application: ELISA

Product Details anti-PIAS2 Antibody

Binding Specificity: AA 1-572

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase PIAS2 protein (1-572AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Alternative Name: PIAS2

Background:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at\'Lys-65\' and \'Lys-160\'.

Aliases: Androgen receptor interacting protein 3 antibody, Androgen receptor-interacting protein 3 antibody, ARIP3 antibody, DAB2 interacting protein antibody, DAB2-interacting protein antibody, DIP antibody, E3 SUMO protein ligase PIAS2 antibody, E3 SUMO-protein ligase PIAS2 antibody, MIZ antibody, Miz1 antibody, Msx interacting zinc finger protein antibody, Msx-interacting zinc finger protein antibody, PIAS NY protein antibody, PIAS-NY protein antibody, PIAS2 antibody, PIAS2_HUMAN antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, Protein inhibitor of activated STAT x antibody, Protein inhibitor of activated STAT, 2 antibody, Protein inhibitor of activated STAT2 antibody, SIZ2 antibody, Zinc finger, MIZ-type containing 4 antibody, ZMIZ4 antibody

UniProt: O75928

Pathways: JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling