NHLRC1 antibody (AA 1-280)

Catalog No. ABIN7151087

Product Details anti-NHLRC1 Antibody

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Binding Specificity: AA 1-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NHLRC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NHLRC1

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Alternative Name: NHLRC1 (NHLRC1 Products)

Synonyms: EPM2A antibody, EPM2B antibody, MALIN antibody, bA204B7.2 antibody, AI505271 antibody, B230309E09Rik antibody, Epm2b antibody, malin-like antibody, NHL repeat containing E3 ubiquitin protein ligase 1 antibody, NHL repeat containing 1 antibody, NHLRC1 antibody, Nhlrc1 antibody

Background:

Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Aliases: bA204B7.2 antibody, E3 ubiquitin-protein ligase NHLRC1 antibody, EPM2A antibody, EPM2B antibody, EPM2B gene antibody, Malin antibody, MGC119262 antibody, MGC119264 antibody, MGC119265 antibody, NHL repeat containing 1 antibody, NHL repeat containing E3 ubiquitin protein ligase 1 antibody, NHL repeat containing protein 1 antibody, NHL repeat-containing protein 1 antibody, NHL repeat-containing protein 1 gene antibody, NHLC1_HUMAN antibody, NHLRC 1 antibody, Nhlrc1 antibody

UniProt: Q6VVB1