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NHLRC1 antibody (AA 86-395) (Biotin)

NHLRC1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7151089
  • Target See all NHLRC1 Antibodies
    NHLRC1 (NHL Repeat Containing 1 (NHLRC1))
    Binding Specificity
    • 4
    • 3
    • 1
    • 1
    AA 86-395
    Reactivity
    • 18
    • 4
    • 2
    • 1
    Human
    Host
    • 16
    • 3
    Rabbit
    Clonality
    • 16
    • 3
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NHLRC1 antibody is conjugated to Biotin
    Application
    • 9
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    NHLRC1 (NHL Repeat Containing 1 (NHLRC1))
    Alternative Name
    NHLRC1 (NHLRC1 Products)
    Synonyms
    EPM2A antibody, EPM2B antibody, MALIN antibody, bA204B7.2 antibody, AI505271 antibody, B230309E09Rik antibody, Epm2b antibody, malin-like antibody, NHL repeat containing E3 ubiquitin protein ligase 1 antibody, NHL repeat containing 1 antibody, NHLRC1 antibody, Nhlrc1 antibody
    Background

    Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

    Aliases: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B

    UniProt
    Q6VVB1
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