UBR2 antibody (AA 101-439) (Biotin)

Catalog No. ABIN7151298

The Rabbit Polyclonal anti-UBR2 antibody has been validated for ELISA. It is suitable to detect UBR2 in samples from Human.

Quick Overview for UBR2 antibody (AA 101-439) (Biotin) (ABIN7151298)

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-UBR2 Antibody (Biotin)

Binding Specificity: AA 101-439

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase UBR2 protein (101-439AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBR2

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Alternative Name: UBR2

Background:

Background: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Aliases: UBR2 antibody, C6orf133 antibody, KIAA0349 antibody, E3 ubiquitin-protein ligase UBR2 antibody, EC 2.3.2.27 antibody, N-recognin-2 antibody, RING-type E3 ubiquitin transferase UBR2 antibody, Ubiquitin-protein ligase E3-alpha-2 antibody, Ubiquitin-protein ligase E3-alpha-II antibody

UniProt: Q8IWV8