NGEF antibody (AA 495-710)

Catalog No. ABIN7151823

The Rabbit Polyclonal anti-NGEF antibody has been validated for ELISA and IF. It is suitable to detect NGEF in samples from Human.

Quick Overview for NGEF antibody (AA 495-710) (ABIN7151823)

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NGEF antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-NGEF Antibody

Binding Specificity: AA 495-710

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ephexin-1 protein (495-710AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NGEF

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Alternative Name: NGEF

Background:

Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Aliases: ARHGEF27 antibody, Eph receptor-interacting exchange protein antibody, Eph-interacting exchange protein antibody, EPHEXIN antibody, Ephexin-1 antibody, Guanine nucleotide exchange factor, neuronal antibody, Neuronal guanine nucleotide exchange factor antibody, Ngef antibody, NGEF_HUMAN antibody

UniProt: Q8N5V2

Pathways: Neurotrophin Signaling Pathway