EYA4 antibody (AA 153-224)

Catalog No. ABIN7152365

Product Details anti-EYA4 Antibody

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Binding Specificity: AA 153-224

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eyes absent homolog 4 protein (153-224AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EYA4

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Alternative Name: EYA4 (EYA4 Products)

Synonyms: B130023L16Rik antibody, CMD1J antibody, DFNA10 antibody, EYA transcriptional coactivator and phosphatase 4 antibody, Eya4 antibody, EYA4 antibody

Background:

Background: Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

Aliases: CMD1J antibody, Deafness, autosomal dominant 10 antibody, DFNA 10 antibody, DFNA10 antibody, dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody, dJ78N10.1 (eyes absent) antibody, EYA 4 antibody, eya4 antibody, EYA4_HUMAN antibody, Eyes absent 4 antibody, Eyes absent homolog 4 (Drosophila) antibody, Eyes absent homolog 4 antibody, HGNC:3522 antibody, OTTHUMP00000040267 antibody

UniProt: O95677

Pathways: Sensory Perception of Sound