FGFR4 antibody (AA 25-182)

Catalog No. ABIN7152841

This anti-FGFR4 antibody is a Rabbit Polyclonal antibody detecting FGFR4 in ELISA, IHC and IF. Suitable for Human.

Quick Overview for FGFR4 antibody (AA 25-182) (ABIN7152841)

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FGFR4 Antibody

Binding Specificity: AA 25-182

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Fibroblast growth factor receptor 4 protein (25-182AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Alternative Name: FGFR4

Background:

Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Aliases: CD 334 antibody, CD334 antibody, CD334 antigen antibody, fc13h 10 antibody, fc13h10 antibody, Fgfr 4 antibody, FGFR-4 antibody, Fgfr4 antibody, FGFR4_HUMAN antibody, Fibroblast growth factor receptor 4 antibody, Hydroxyaryl protein kinase antibody, JTK 2 antibody, JTK2 antibody, MGC20292 antibody, Protein tyrosine kinase antibody, TKF antibody, Tyrosine kinase related to fibroblast growth factor receptor antibody, Tyrosylprotein kinase antibody

UniProt: P22455

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding